The Photodynamic Action of 6-Mercaptopurine on Deoxyribonucleic Acid (DNA)
نویسندگان
چکیده
منابع مشابه
Studies on the Anti-inflammatory Action of 6-mercaptopurine
The mechanism of action of 6-mercaptopurine (6-MP) on an egg albumin-induced inflammatory lesion in the skin has been studied in rabbits treated with 6-MP in a daily dosage of 18 mg/kg. Relative to control animals, significant decreases in the numbers of large lymphocytes and monocytes in the blood were observed in the 6-MP-treated animals by the 9th day of treatment, without significant decrea...
متن کاملThe Mechanism of Action of 6-mercaptopurine. I. Biochemical Effects.
systems (3—5,12, 13, 17, 18) have led to the hypothesis that the active form of 6-MP is its ribonucleotide (thio inosinate, 6-thio IMP), which inhibits the further conver sion by inosinate to other purine ribonucleotides (4, 5). This inhibition by thioinosinate of the formation of ade nylate and guanylate has been demonstrated in cell-free preparations from Streptococcus faecalis and pigeon l...
متن کاملMechanism of action of micrococcal nuclease on deoxyribonucleic acid.
Two types of methods have been used for the elucidation of specificity (or preference) of nucleases when complex polynucleotides are used as substrates. One method depends on the identification of products in the digest. I f a particular combination (or combinations) is missing, it means that this combination is preferentially attacked. Thus, in the case of pancreatic ribonuclease, sequences Py...
متن کاملhistological evaluation of the effect of three medicaments; trichloracetic acid, formocresol and mineral trioxide aggregate on pulpotomized teeth of dogs
چکیده ندارد.
15 صفحه اولAction of haemophilus endodeoxyribonuclease on biologically active deoxyribonucleic acid.
An enzyme similar to that described by Smith and Wilcox (15) for Haemophilus influenzae which attacks foreign deoxyribonucleic acid (DNA) but not its own has been isolated and purified from H. parainfluenzae. The enzyme degrades foreign DNA to limited sizes and can destroy the transforming activity of H. influenzae and Bacillus subtilis DNA. The enzyme can also destroy the biological activity o...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1980
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.100.3_342